March 1, 2017
| 9:00 a.m. – 10:30 a.m. |
Registration |
| 10:30 a.m. – 11:00 a.m. |
Welcome Simone Fulda - CongressChair Rainer Engers - AEK Chair |
| 11:00 a.m. – 1:00 p.m. |
Symposium 1: Targeting Transcription and MYC Chairs: Peter Angel, Heidelberg; Martin Eilers, Wuerzburg |
| 11:00 a.m. – 11:30 a.m. | Gerard Evan, Cambridge |
| 11:30 a.m. – 12:00 a.m. | David Rickman, New York |
| 12:00 a.m. – 12:30 p.m. | Jay Bradner, Cambrige Targeted Protein Degradation |
| 12:30 p.m. – 12:45 p.m. | Klaus-Peter Janssen, Munich: Dual specificity phosphatase 5 (DUSP5): a new tumor suppressor in colorectal cancer counteracting the RAS/MAPK-pathway (Abstract 0222) |
| 12:45 p.m. – 1:00 p.m. | Carsten Ade, Wuerzburg: Targeting oncogenic functions of Myc in solid tumors (Abstract 0289) |
| 1:00 p.m. – 2:00 p.m. |
Lunch Break |
| 2:00 p.m. – 3:30 p.m. |
Symposium 2: Precision Oncology: from bench to bedside Chairs: Jens Hoffmann, Berlin; Lars Zender, Tuebingen |
| 2:00 p.m. – 2:30 p.m. | Stefan Pfister, Heidelberg: (Brain) Tumor Classification Based on Cellular Origins |
| 2:30 p.m. – 3:00 p.m. | Christophe le Tourneau, Paris: Designs and challenges for precision medicine studies in oncology |
| 3:00 p.m. – 3:15 p.m. | Ramona Schulz-Heddergott, Goettingen: Dependency of established colorectal cancers on mutant p53 driving STAT3-mediated proliferation and invasion (Abstract 0092) |
| 3:15 p.m. – 3:30 p.m. | Christian Regenbrecht, Berlin: Reconstructing intra-tumor heterogeneity: Lessons from therapeutic intervention in patient-specific models (Abstract 0298) |
| 3:30 p.m. – 5:00 p.m. |
Coffee break & Poster Session 1 |
| 5:00 p.m. – 6:00 p.m. |
Keynote Lecture Chair: Simone Fulda, Frankfurt/Main Eileen White, New Brunswick |
| 6:00 p.m. – 7:00 p.m. |
"Deutscher Krebspreis 2017" (German Cancer Award) & "Karl-Heinrich-Bauer-Medaille 2017" (Karl-Heinrich-Bauer-Medal) |
| 7:00 p.m. |
Welcome Reception "Wine and Cheese" |
March 2, 2017
| 9:00 a.m. – 11:00 a.m. | Symposium 3: Programmed cell death revisited Chairs: Simone Fulda, Frankfurt/Main; Roland Moll, Marburg |
| 9:00 a.m. – 9:30 a.m. | Doug Green, Memphis: Cell Death and Resuscitation: To the Edge of Necroptosis and Back |
| 9:30 a.m. – 10:00 a.m. | Peter Vandenabeele, Gent: Disease relevant and therapeutic opportunities of regulated necrosis: role of ferroptosis in cancer treatment and immunogenic cell death (ICD) |
| 10:00 a.m. – 10:30 a.m. | Anthony Letai, Boston: Precision Cancer Medicine with Mitochondrial BH3 Profiling |
| 10:30 a.m. – 10:45 a.m. | Meike Vogler, Leicester: Novel insights into the inhibition of BCL2 proteins as a therapeutic strategy in Diffuse Large B-Cell Lymphoma (Abstract 0157) |
| 10:45 a.m. – 11:00 a.m. | Andreas Villunger, Innsbruck: The PIDDosome activates p53 in response to supernumerarary centrosomes (Abstract 0176) |
| 11:00 a.m. – 11:30 a.m. | Coffee break |
| 11:30 a.m. – 1:00 p.m. |
Symposium 4: Therapeutic exploitation of DNA damage & repair pathways Chairs: Matthias Dobbelstein, Goettingen; Lisa Wiesmüller, Ulm |
| 11:30 a.m. – 12:00 a.m. | Oscar Fernandez-Capetillo, Madrid: Mechanisms of resistance to anticancer therapies |
| 12:00 a.m. – 12:30 p.m. | Christian Reinhardt, Cologne: Defect in the DNA damage response a actionable molecular vulnerabilities in cancer |
| 12:30 p.m. – 12:45 p.m. | Holger Bastians, Goettingen: A mechanistic link between chromosomal instability and mestastasis in human cancer (Abstract 0009) |
| 12:45 p.m. – 1:00 p.m. | Stephanie Hampp, Ulm: DNA damage tolerance pathway involving DNA polymerase iota and the tumor suppressor p53 regulates DNA replication fork progression (Abstract 0090) |
| 1:00 p.m. – 2:00 p.m. | Lunch break |
| 2:00 p.m. – 3:30 p.m. | Symposium 5: Autophagy & Ubiquitin-dependent signaling Chairs: Nisar Malek, Tuebingen; Bernd Groner, Frankfurt |
| 2:00 p.m. – 2:30 p.m. | Vishva Dixit, San Francisco: Shedding light on Post-transcriptional regulatory mechanisms in cell signaling |
| 2:30 p.m. – 3:00 p.m. | Kevin Ryan, Glasgow: Mechanisms of Macroautophagy in Cell Death and Cancer |
| 3:00 p.m. – 3:15 p.m. | Sonja Lorenz, Wuerzburg: Structural regulation of the ubiquitin ligase HUWE1 in cancer signaling (Abstract 0230) |
| 3:15 p.m. – 3:30 p.m. | Nikita Popov, Wuerzburg: Regulation of the SCF(beta-TrCP) ubiquitin ligase during DNA damage response (Abstract 0276) |
| 3:30 p.m. – 5:00 p.m. | Coffee break & Poster Session 2 |
| 5:00 p.m. – 6:30 p.m. | Symposium 6: Targeting the Vulnerabilities of Cancer Chairs: Uta E. Hoepken, Berlin; Rainer Engers, Duesseldorf |
| 5:00 p.m. – 5:30 p.m. | Florian Bassermann, Munich: Aberrant ubiquitin networks in B-cell malignancies |
| 5:30 p.m. – 6:00 p.m. | Clemens Schmitt, Berlin: Restoring Senescence by Targeting an Epigenetic Vulnerability in Melanoma |
| 6:00 p.m. – 6:15 p.m. | Katharina Wolter, Tuebingen: Induction of Ribosomal checkpoint Induced Senescence (RCIS) for the Treatment of Liver Cancer (Abstract 0234) |
| 6:15 p.m. – 6:30 p.m. | Stefanie Peter, Wuerzburg: Loss of APC induces a dependence on elevated eIF2B5 function in colorectal cancer (Abstract 0221) |
| 6:30 p.m. – 7:30 p.m. |
AEK Member Assembly |
| 8:00 p.m. |
Social Get-together |
March 3, 2017
| 9:00 a.m. – 10:30 a.m. |
Symposium 7: Tumor heterogeneity & cancer evolution Chair: Petra Boukamp, Heidelberg |
| 9:00 a.m. – 9:30 a.m. | Jean-Christophe Marine, Leuven: From new insights into melanoma biology to improved targeted therapeutic modalities |
| 9:30 a.m. – 10:00 a.m. | Johannes Zuber, Vienna: Exploring and exploiting aberrant self-fate programs in leukemia |
| 10:00 a.m. - 10:15 a.m. | Lauritz Miarka, Kiel: Role of TRAIL death receptors in metastasis of pancreatic cancer (Abstract 0172) |
| 10:15 a.m. - 10:30 a.m. | Marco Seehawer, Tuebingen: Necroptosis dependent cytokine microenvironment determines lineage commitment in liver tumorigenesis via epigenetic regulation (Abstract 0303) |
| 10:30 a.m. – 11:00 a.m. |
Coffee break |
| 11:00 a.m. – 12:00 a.m. |
Keynote Lecture Chair: Lars Zender, Tuebingen Scott Lowe, New York |
| 12:00 a.m. – 1:00 p.m. |
Symposium 8: New concepts to target RAS Chairs: Reinhold Schaefer, Berlin; Klaus-Peter Janssen, Munich |
| 12:00 a.m. – 12:30 p.m. | Rene Bernards, Amsterdam: Finding vulnerabilities of drug-resistant cancer |
| 12:30 p.m. – 1:00 p.m. | Richard Marais, Manchester: Developing precision medicine for melanoma |
| 1:00 p.m. |
Poster Prizes and concluding remarks |
| 1:15 p.m. |
Welfare Lunch |